Atrial fibrillation (AFib)

Understanding Atrial Fibrillation

Atrial fibrillation (AFib) and thrombosis: What you need to know

Atrial fibrillation (AFib) blood clots represent one of the most serious complications of the world’s most common heart rhythm disorder. AFib affects more than 2.6 million Americans, with projections showing this number will reach 12 million by 2050 as the population ages, according to the National Blood Clot Alliance.

When AFib disrupts your heart’s normal electrical signals, the upper chambers (atria) beat chaotically instead of contracting in a coordinated rhythm. This irregular heartbeat creates dangerous conditions within your heart where blood can pool and form life-threatening clots.

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Atrial fibrillation (AFib)

Patient facing flyer on AFib
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The deadly connection between AFib and stroke

AFib occurs when AFib-related blood clots break free from the heart and travel through the circulatory system. These clots most commonly lodge in brain arteries, causing ischemic strokes that are twice as likely to result in death or permanent disability compared to strokes from other causes.

Beyond stroke risk, emerging evidence published in Research and Practice in Thrombosis and Haemostasis (RPTH) shows AFib patients also face increased risks of pulmonary embolism and other thromboembolic events. The clots can travel to arteries in the legs, arms and other vital organs, creating multiple pathways for serious complications.

People with AFib are at a greater risk for stroke and are estimated to account for 15 percent of the 15 million strokes that occur worldwide every year. 1 2

Silent but dangerous: The challenge of asymptomatic AFib

Many people with AFib blood clots experience no symptoms, making early detection crucial for preventing catastrophic outcomes. While some patients notice heart palpitations, irregular pulse or chest discomfort, studies show that asymptomatic AFib cases often go undiagnosed until a stroke or other major event occurs.

The ISTH Scientific and Standardization Committee (SSC) emphasizes that healthcare providers must maintain high clinical suspicion for AFib in at-risk populations, particularly older adults with cardiovascular disease, hypertension or diabetes. Regular pulse checks and electrocardiogram screenings can identify irregular heart rhythms before dangerous clots form.

This silent nature of AFib makes understanding your personal risk factors and seeking appropriate medical evaluation essential for preventing life-threatening complications from atrial fibrillation blood clots.

How to detect atrial fibrillation symptoms and get proper diagnosis

Recognizing AFib symptoms early can prevent dangerous blood clots and stroke. While many people ignore their heartbeat, millions worldwide live with AFib, a heart rhythm disorder where electrical signals become rapid, irregular and disorganized. This irregular heartbeat detection is crucial because AFib often occurs without obvious warning signs.

Simple pulse check for AFib detection

If you suspect AFib symptoms, a basic pulse check can reveal irregular heart rhythms. Place your index and middle fingers on the inside of your left wrist and feel for your pulse. Focus on the rhythm and pattern rather than counting beats. An irregular, chaotic pulse pattern may indicate AFib and requires immediate medical evaluation.

AFib diagnosis process and medical testing

When you experience irregular heartbeat symptoms, your doctor will conduct a comprehensive AFib diagnosis evaluation. This systematic approach includes:

Medical history assessment:

  • Duration and nature of your symptoms
  • Existing medical conditions
  • Alcohol consumption patterns
  • Family history of AFib or heart disease
  • Thyroid condition history

Physical examination and testing: Your healthcare provider will listen to your heart with a stethoscope and check your pulse manually. If AFib symptoms are suspected, additional AFib testing typically includes:

  • Electrocardiogram (ECG) – The gold standard for diagnosing irregular heart rhythms
  • Blood tests – To identify underlying conditions contributing to AFib
  • Extended monitoring – For patients with intermittent symptoms
Many people with atrial fibrillation blood clots experience no symptoms, making early detection crucial for preventing catastrophic outcomes

AFib risk factors

Understanding your atrial fibrillation risk factors is crucial for preventing dangerous blood clots and stroke. While AFib can affect anyone, certain medical conditions, lifestyle choices and demographic factors significantly increase your likelihood of developing this irregular heart rhythm. Age remains the most powerful predictor, with AFib risk doubling with each decade after 50. However, multiple risk factors often work together, creating compound dangers that require careful medical monitoring and preventive strategies.

Key AFib risk factors

  • Age- the older a person is, the greater the risk of developing it
  • Heart & vascular disease
  • High blood pressure
  • Thyroid disease
  • Other chronic health conditions
  • Drinking alcohol
  • Diabetes
  • Obesity
  • Family history
  • Overactive thyroid
  • Blood clot in the lung
  • Males are at a higher risk
ISTH

Research on atrial fibrillation from the International Society on Thrombosis and Haemostasis (ISTH)

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Page References:

  • Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study. Arch Intern Med 1987;147:1561-4.
  • Kannel WB, Benjamin EJ. Status of the epidemiology of atrial fibrillation. Med Clin North Am 2008;92:17-40.
  • Paciaroni M, Agnelli G, Caso V, et al. Atrial fibrillation in patients with first-ever stroke: frequency, antithrombotic treatment before the event and effect on clinical outcome. J Thromb Haemost 2005;3(6):1218-23. PMID: 15892862.
  • Hansen, J.B., et al. (2025). Joint effects of atrial fibrillation and prothrombotic genotypes on the risk of venous thromboembolism. Research and Practice in Thrombosis and Haemostasis, 9(4). https://doi.org/10.1016/j.rpth.2025.102880
  • Hansen, S.M., et al. (2017). Atrial Fibrillation and Cause‐Specific Risks of Pulmonary Embolism and Ischemic Stroke. Journal of the American Heart Association, 6(11). https://www.ahajournals.org/doi/10.1161/jaha.117.006502
  • Kaatz, S., et al. (2015). Definition of clinically relevant non‐major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non‐surgical patients: communication from the SSC of the ISTH. Journal of Thrombosis and Haemostasis, 13(11). https://pubmed.ncbi.nlm.nih.gov/26764429/
  • Delluc, A., et al. (2019). Anticoagulation of cancer patients with non-valvular atrial fibrillation receiving chemotherapy: Guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis, 17(8):1247-1252. https://pubmed.ncbi.nlm.nih.gov/31207027/
  • International Society on Thrombosis and Haemostasis. (2025). Published Guidance. https://www.isth.org/page/Published_Guidance
  • Research and Practice in Thrombosis and Haemostasis Journal. (2025). https://www.rpthjournal.org/
  • National Blood Clot Alliance. (2022). Atrial Fibrillation (AFib) and Clot-Provoked Stroke. https://www.stoptheclot.org/about-clots/afib-2/